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Version: 17.10e (Release date: 2017-10-30)
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YM598 (Code C26678)

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Terms & Properties

Preferred Name: YM598

Definition: An orally active synthetic substituted phenylethenesulfonamide. As a selective endothelin A receptor antagonist, YM598 inhibits endothelin-mediated mechanisms involved in tumor cell growth and progression, angiogenesis, and metastasis. (NCI04)

NCI-GLOSS Definition: A substance that is being studied as a treatment for advanced prostate cancer and for pain caused by prostate cancer that has spread to the bone. It belongs to the family of drugs called endothelin ETA receptor antagonists.

Label: YM598

NCI Thesaurus Code: C26678 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1175067  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Potassium (E)-N-[6-methoxy-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylenthene Sulfonamidate

External Source Codes: 
PDQ Closed Trial Search ID 270682
PDQ Open Trial Search ID 270682 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 16843458 (see PubMed Primary Reference info)
UMLS CUI C1175067

Other Properties:
     Name Value (qualifiers indented underneath)
code C26678
Legacy_Concept_Name YM598
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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