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Version: 17.06d (Release date: 2017-06-26)
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Sunitinib Malate (Code C26673)

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Terms & Properties

Preferred Name: Sunitinib Malate

Definition: The orally bioavailable malate salt of an indolinone-based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells.

NCI-GLOSS Definition: A drug used to treat gastrointestinal stromal tumors (GIST) that have not responded to treatment with imatinib mesylate (Gleevec). SU011248 is also used to treat advanced kidney cancer and is being studied in the treatment of other types of cancer. It is a type of tyrosine kinase inhibitor, a type of vascular endothelial growth factor (VEGF) receptor inhibitor, and a type of angiogenesis inhibitor.

Display Name: Sunitinib Malate

Label: Sunitinib Malate

NCI Thesaurus Code: C26673 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1700685  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Butanedioic acid, hydroxy-, (2S)-, compd. with N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1)
SU011248
SU11248
sunitinib
Sunitinib Malate
sunitinib malate
SUNITINIB MALATE
Sutent

External Source Codes: 
CAS Registry Number 341031-54-7 (see NLM ChemIDplus info)
FDA UNII Code LVX8N1UT73
NSC Code 736511 (see NCI DTP info)
PDQ Closed Trial Search ID 299061
PDQ Open Trial Search ID 299061 (check for NCI PDQ open clinical trial info)
UMLS CUI C1700685

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Gastrointestinal Stromal Tumor; Advanced Metastatic Renal Cell Carcinoma
Chemical_Formula C22H27FN4O2.C4H6O5
code C26673
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name SU11248
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26673

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