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Version: 16.11d (Release date: 2016-11-28)
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Sildenafil Citrate (Code C26670)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Sildenafil Citrate

Definition: The citrate salt of a pyrazolopyrimidinone derivative structurally related to zaprinast. Sildenafil selectively inhibits cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase, resulting in vasodilation in the corpus cavernosum of the penis and penile erection. (NCI04)

NCI-GLOSS Definition: A drug used to treat erectile dysfunction. Viagra relaxes the smooth muscle of the penis to allow increased blood flow and erection. It is a type of phosphodiesterase inhibitor.

Display Name: Sildenafil Citrate

Label: Sildenafil Citrate

NCI Thesaurus Code: C26670 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0724693  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Revatio
sildenafil
Sildenafil Citrate
SILDENAFIL CITRATE
Viagra

External Source Codes: 
CAS Registry Number 171599-83-0 (see NLM ChemIDplus info)
FDA UNII Code BW9B0ZE037
ChEBI ID CHEBI:58987 (see ChEBI info)
PDQ Closed Trial Search ID 269137
PDQ Open Trial Search ID 269137 (check for NCI PDQ open clinical trial info)
UMLS CUI C0724693

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Erectile dysfunction
Chemical_Formula C22H30N6O4S.C6H8O7
code C26670
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Sildenafil_Citrate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26670

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