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Version: 16.11d (Release date: 2016-11-28)
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Zileuton (Code C26667)

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Terms & Properties

Preferred Name: Zileuton

Definition: A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma. (NCI04)

NCI-GLOSS Definition: A substance that is used to prevent asthma symptoms and that is being studied in the prevention of lung cancer. It belongs to the family of drugs called leukotriene blockers.

Display Name: Zileuton

Label: Zileuton

NCI Thesaurus Code: C26667 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0081408  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea
N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea
Zileuton
ZILEUTON
zileuton
Zyflo

External Source Codes: 
CAS Registry Number 111406-87-2 (see NLM ChemIDplus info)
FDA UNII Code V1L22WVE2S
ChEBI ID CHEBI:10112 (see ChEBI info)
NSC Code 730712 (see NCI DTP info)
PDQ Closed Trial Search ID 285649
PDQ Open Trial Search ID 285649 (check for NCI PDQ open clinical trial info)
UMLS CUI C0081408

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Prevention and Chronic treatment of Asthma
Chemical_Formula C11H12N2O2S
code C26667
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Zileuton
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26667

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