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Version: 17.06d (Release date: 2017-06-26)
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Tarenflurbil (Code C26666)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Tarenflurbil

Definition: An orally active synthetic enantiomer of flurbiprofen. Tarenflurbil activates c-Jun N terminal kinase, increases AP-1 binding to DNA, and downregulates cyclin D1 expression, resulting in arrest of tumor cells in the G1 phase of the cell cycle and apoptosis. This agent also affects the expression of nuclear factor kappa B, a rapid response transcription factor that stimulates the immune response to tumor cells. R-flurbiprofen does not inhibit the enzyme cyclo-oxygenase.

NCI-GLOSS Definition: A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs).

Label: Tarenflurbil

NCI Thesaurus Code: C26666 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1527219  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(R)-2-Fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic Acid
E-7869
Flurizan
MPC-7869
R-flurbiprofen
R-Flurbiprofen
TARENFLURBIL
Tarenflurbil

External Source Codes: 
CAS Registry Number 51543-40-9 (see NLM ChemIDplus info)
FDA UNII Code 501W00OOWA
ChEBI ID CHEBI:38666 (see ChEBI info)
NSC Code 685699 (see NCI DTP info)
PDQ Closed Trial Search ID 257154
PDQ Open Trial Search ID 257154 (check for NCI PDQ open clinical trial info)
UMLS CUI C1527219

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H13FO2
code C26666
Contributing_Source FDA
Legacy_Concept_Name R-flurbiprofen
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26666

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