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Version: 17.06d (Release date: 2017-06-26)
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MLN2704 (Code C26660)

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Terms & Properties

Preferred Name: MLN2704

Definition: An immunoconjugate that consists of a humanized monoclonal antibody (MLN591), directed against prostate-specific membrane antigen linked to a maytansinoid (DM1). The monoclonal antibody moiety of MLN2704 binds to tumor cells expressing prostate-specific membrane antigen; MLN274 is then internalized into the tumor cell where the DM1 maytansinoid moiety binds to tubulin and inhibits tubulin polymerization and microtubule assembly, resulting in a disruption of microtubule activity and cell division, and cell death. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the treatment of prostate cancer. It belongs to the family of drugs called antibody drug conjugates.

Label: MLN2704

NCI Thesaurus Code: C26660 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1327945  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MLN2704
MLN591DM1

External Source Codes: 
PDQ Closed Trial Search ID 299464
PDQ Open Trial Search ID 299464 (check for NCI PDQ open clinical trial info)
UMLS CUI C1327945

Other Properties:
     Name Value (qualifiers indented underneath)
code C26660
Legacy_Concept_Name MLN2704
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26660

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