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Version: 17.12d (Release date: 2017-12-26)
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Enzastaurin Hydrochloride (Code C26658)

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Terms & Properties

Preferred Name: Enzastaurin Hydrochloride

Definition: The hydrochloride salt of enzastaurin, a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden.

NCI-GLOSS Definition: A substance being studied in the treatment of certain types of cancer, including non-Hodgkin lymphoma, breast, colon, lung, ovarian, and prostate. Enzastaurin hydrochloride blocks certain cell signaling pathways, and may prevent the growth of new blood vessels that tumors need to grow. It is a type of serine threonine kinase inhibitor and a type of antiangiogenesis agent.

Display Name: Enzastaurin Hydrochloride

Label: Enzastaurin Hydrochloride

NCI Thesaurus Code: C26658 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1615613  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione Dihydrochloride
Enzastaurin Hydrochloride
enzastaurin hydrochloride

External Source Codes: 
CAS Registry Number 359017-79-1 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 269069
PDQ Open Trial Search ID 269069 (check for NCI PDQ open clinical trial info)
UMLS CUI C1615613

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C32H29N5O2.HCl
code C26658
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name LY317615
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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