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Version: 17.06d (Release date: 2017-06-26)
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Forodesine Hydrochloride (Code C26655)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Forodesine Hydrochloride

Definition: The hydrochloride salt of the synthetic high-affinity transition-state analogue forodesine. Forodesine binds preferentially to and inhibits purine nucleotide phosphorylase (PNP), resulting in the accumulation of deoxyguanosine triphosphate and the subsequent inhibition of the enzyme ribonucleoside diphosphate reductase and DNA synthesis. This agent selectively causes apoptosis in stimulated or malignant T-lymphocytes. A transition state analogue is a substrate designed to mimic the properties or the geometry of the transition state of reaction.

NCI-GLOSS Definition: A substance being studied in the treatment of some types of leukemia and lymphoma. It is a type of purine nucleoside phosphorylase (PNP) inhibitor.

Display Name: Forodesine Hydrochloride

Label: Forodesine Hydrochloride

NCI Thesaurus Code: C26655 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1175653  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BCX-1777
Forodesine Hydrochloride
FORODESINE HYDROCHLORIDE
forodesine hydrochloride
Immucillin-H

External Source Codes: 
CAS Registry Number 284490-13-7 (see NLM ChemIDplus info)
FDA UNII Code 6SN82Y9U73
PDQ Closed Trial Search ID 301648
PDQ Open Trial Search ID 301648 (check for NCI PDQ open clinical trial info)
UMLS CUI C1175653

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C11H14N4O4.HCl
code C26655
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Immucillin-H
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26655

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