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Version: 17.06d (Release date: 2017-06-26)
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Hexaminolevulinate (Code C26654)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Hexaminolevulinate

Definition: The hexyl ester of 5-aminolevulinic acid (ALA) with photodynamic properties. As a precursor of photoactive porphorins, hexyl 5-aminolevulinate induces the endogenous production of the photosensitizer protoporphyrin IX (PPIX) which accumulates selectively in tumor tissue. When exposed to specific wavelengths of light, PPIX is activated and, depending on the wavelength and/or intensity of light, either fluoresces, thereby allowing tumor imaging, or induces tumor cell apoptosis.

NCI-GLOSS Definition: A substance that is used to find and kill tumor cells. It enters tumor cells and becomes activated when exposed to a special type of light. A chemical reaction causes the cells to produce fluorescent light and die.

Display Name: Hexaminolevulinate

Label: Hexaminolevulinate

NCI Thesaurus Code: C26654 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1327841  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HAL
Hexaminolevulinate
HEXAMINOLEVULINATE
HexvixR
hexyl 5-aminolevulinate
Hexyl 5-Aminolevulinate

External Source Codes: 
CAS Registry Number 140898-97-1 (see NLM ChemIDplus info)
FDA UNII Code G7H20TKI67
PDQ Closed Trial Search ID 269130
PDQ Open Trial Search ID 269130 (check for NCI PDQ open clinical trial info)
UMLS CUI C1327841

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C11H21NO3
code C26654
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Hexyl_5-Aminolevulinate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26654

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