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Version: 17.06d (Release date: 2017-06-26)
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GTI-2040 (Code C26652)

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Terms & Properties

Preferred Name: GTI-2040

Definition: A 20-mer antisense oligonucleotide complementary to a coding region in the mRNA of the R2 small subunit component of human ribonucleotide reductase. GTI-2040 decreases mRNA and protein levels of R2 in vitro and may inhibit tumor cell proliferation in human tumors in vivo. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It blocks the production of a protein called ribonucleotide reductase, which helps cells make DNA. This may kill cancer cells that need ribonucleotide reductase to grow. It may also make cells more sensitive to anticancer drugs. It is a type of antisense oligonucleotide, and a type of ribonucleotide reductase inhibitor.

Display Name: GTI-2040

Label: GTI-2040

NCI Thesaurus Code: C26652 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1142995  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GTI-2040

External Source Codes: 
CAS Registry Number 236391-66-5 (see NLM ChemIDplus info)
NSC Code 722929 (see NCI DTP info)
PDQ Closed Trial Search ID 301635
PDQ Open Trial Search ID 301635 (check for NCI PDQ open clinical trial info)
UMLS CUI C1142995

Other Properties:
     Name Value (qualifiers indented underneath)
code C26652
Contributing_Source CTRP
Legacy_Concept_Name GTI-2040
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26652

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