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Version: 17.06d (Release date: 2017-06-26)
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Edotecarin (Code C2665)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Edotecarin

Definition: A synthetic indolocarbazole with antineoplastic activity. Edotecarin inhibits the enzyme topoisomerase I through stabilization of the DNA-enzyme complex and enhanced single-strand DNA cleavage, resulting in inhibition of DNA replication and decreased tumor cell proliferation. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It is a type of topoisomerase I inhibitor.

Label: Edotecarin

NCI Thesaurus Code: C2665 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1328673  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6-N-(1-hydroxymethyla-2-hydroxy)ethylamino-12,13-dihydro-13-(beta-D-gluco pyranosyl)-5H-indolo[2,3-a]-pyrrolol[3,4-c]-carbazole-5,7(6H)-dione
Edotecarin
EDOTECARIN
edotecarin
J-107088

External Source Codes: 
CAS Registry Number 174402-32-5 (see NLM ChemIDplus info)
FDA UNII Code 1V8X590XDP
PDQ Closed Trial Search ID 38537
PDQ Open Trial Search ID 38537 (check for NCI PDQ open clinical trial info)
UMLS CUI C1328673

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C29H28N4O11
code C2665
Contributing_Source FDA
Legacy_Concept_Name Edotecarin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2665

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