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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Edotecarin (Code C2665)

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Terms & Properties

Preferred Name: Edotecarin

Definition: A synthetic indolocarbazole with antineoplastic activity. Edotecarin inhibits the enzyme topoisomerase I through stabilization of the DNA-enzyme complex and enhanced single-strand DNA cleavage, resulting in inhibition of DNA replication and decreased tumor cell proliferation. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It is a type of topoisomerase I inhibitor.

Label: Edotecarin

NCI Thesaurus Code: C2665 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1328673  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6-N-(1-hydroxymethyla-2-hydroxy)ethylamino-12,13-dihydro-13-(beta-D-gluco pyranosyl)-5H-indolo[2,3-a]-pyrrolol[3,4-c]-carbazole-5,7(6H)-dione

External Source Codes: 
CAS Registry Number 174402-32-5 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 38537
PDQ Open Trial Search ID 38537 (check for NCI PDQ open clinical trial info)
UMLS CUI C1328673

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C29H28N4O11
code C2665
Contributing_Source FDA
Legacy_Concept_Name Edotecarin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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