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Version: 16.11d (Release date: 2016-11-28)
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Eribulin Mesylate (Code C26644)

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Terms & Properties

Preferred Name: Eribulin Mesylate

Definition: The mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression.

NCI-GLOSS Definition: A drug used to treat metastatic breast cancer in patients who have already been treated with other chemotherapy. It is also being studied in the treatment of other types of cancer. Halaven may block cancer cell growth by stopping cell division. It belongs to the family of drugs called antitubulin agents.

Display Name: Eribulin Mesylate

Label: Eribulin Mesylate

NCI Thesaurus Code: C26644 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2608038  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-(3-Amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one
B1939 Mesylate
E7389
ER-086526
Eribulin Mesylate
ERIBULIN MESYLATE
eribulin mesylate
Halaven
Halichondrin B Analog

External Source Codes: 
CAS Registry Number 253128-41-5 (see NLM ChemIDplus info)
FDA UNII Code AV9U0660CW
NSC Code 707389 (see NCI DTP info)
PDQ Closed Trial Search ID 257773
PDQ Open Trial Search ID 257773 (check for NCI PDQ open clinical trial info)
UMLS CUI C2608038

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Breast Cancer
Chemical_Formula C40H59NO11.CH4O3S
code C26644
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name E7389
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26644

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