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Version: 17.06d (Release date: 2017-06-26)
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Buspirone Hydrochloride (Code C26641)

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Terms & Properties

Preferred Name: Buspirone Hydrochloride

Definition: The hydrochloride salt of an anxiolytic agent chemically and pharmacologically unrelated to benzodiazepines, barbiturates, or other sedative/hypnotic drugs. Although its exact mechanism of action is unknown, buspirone may exert its anti-anxiety effects via serotonin (5-HT1A) and dopamine receptors (D2) and may indirectly affect other neurotransmitter systems. Unlike typical benzodiazepine anxiolytics, this agent does not exert anticonvulsant or muscle relaxant effects and lacks prominent sedative effects.

Display Name: Buspirone Hydrochloride

Label: Buspirone Hydrochloride

NCI Thesaurus Code: C26641 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700444  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Buspirone Hydrochloride
BUSPIRONE HYDROCHLORIDE

External Source Codes: 
CAS Registry Number 33386-08-2 (see NLM ChemIDplus info)
FDA UNII Code 207LT9J9OC
ChEBI ID CHEBI:3224 (see ChEBI info)
PDQ Closed Trial Search ID 270391
PDQ Open Trial Search ID 270391 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700444

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For alcohol abuse; anxiety; depression; migraine prophylaxis; smoking cessation; panic disorder.
Chemical_Formula C21H31N5O2.HCl
code C26641
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Buspirone
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26641

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