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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Fibrin Sealant (Code C2664)

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Terms & Properties

Preferred Name: Fibrin Sealant

Definition: A plasma-derived fibrin biomatrix preparation consisting of two separate solutions that are combined on application. The sealer protein solution contains clottable human fibrinogen and bovine aprotinin, a fibrinolysis inhibitor; the thrombin solution contains human thrombin and calcium chloride. When the solutions are combined, a clot is formed, reproducing the final stages of the coagulation cascade.

NCI-GLOSS Definition: A substance used during surgery to help heal wounds. It contains proteins found in human blood that cause blood to clot. When fibrin sealant is placed on a wound, a clot forms. Fibrin sealant is being studied as a way to improve healing after lymph node removal in patients with cancer. It is a type of surgical glue.

Display Name: Fibrin Sealant

Label: Fibrin Sealant

NCI Thesaurus Code: C2664 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0947703  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Beriplast P
Fibrin Sealant
fibrin sealant

External Source Codes: 
PDQ Closed Trial Search ID 38531
PDQ Open Trial Search ID 38531 (check for NCI PDQ open clinical trial info)
UMLS CUI C0947703

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Cardiovascular Surgery; Colostomy Closure; Congenital Heart Defects; Coronary Artery Bypass Grafting; Mediastinal Bleeding; Microvascular Bleeding; Splenic Trauma.
code C2664
Contributing_Source CTRP
Legacy_Concept_Name Fibrin_Sealant
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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