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Version: 17.06d (Release date: 2017-06-26)
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Clofarabine (Code C26638)

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Terms & Properties

Preferred Name: Clofarabine

Definition: A second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5'-triphosphate metabolite, which inhibits the enzymatic activities of ribonucleotide reductase and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factors, which activate apoptosis.

NCI-GLOSS Definition: A drug used to treat certain types of acute lymphoblastic leukemia in children. It is also being studied in the treatment of other types of cancer. Clolar is a type of nucleoside analog.

Display Name: Clofarabine

Label: Clofarabine

NCI Thesaurus Code: C26638 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0092777  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 123318-82-1 (see NLM ChemIDplus info)
ChEBI ID CHEBI:681569 (see ChEBI info)
ChEBI ID CHEBI:47311 (see ChEBI info)
NSC Code 606869 (see NCI DTP info)
PDQ Closed Trial Search ID 257309
PDQ Open Trial Search ID 257309 (check for NCI PDQ open clinical trial info)
UMLS CUI C0092777

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acute lymphoblastic leukemia, pediatric
Chemical_Formula C10H11ClFN5O3
code C26638
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Clofarabine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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