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Version: 17.06d (Release date: 2017-06-26)
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R(+)XK469 (Code C2662)

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Terms & Properties

Preferred Name: R(+)XK469

Definition: The R-isomer of a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases, stimulates caspases, and upregulates p53-dependent proteins, including cyclins A and B1, thereby arresting cancer cells in the G2/M phase of the cell cycle. Both R(+) and S(-) isomers of this agent are cytotoxic, although the R-isomer is more potent. (NCI05)

NCI-GLOSS Definition: A substance that is being studied in the treatment of leukemia. It belongs to the family of drugs called topoisomerase inhibitors.

Display Name: R(+)XK469

Label: R(+)XK469

NCI Thesaurus Code: C2662 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0765292  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid
Propanoic acid, 2-[4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy]-, (+ )-(R)-

External Source Codes: 
NSC Code 698215 (see NCI DTP info)
PDQ Closed Trial Search ID 38517
PDQ Open Trial Search ID 38517 (check for NCI PDQ open clinical trial info)
UMLS CUI C0765292

Other Properties:
     Name Value (qualifiers indented underneath)
code C2662
Contributing_Source CTRP
Legacy_Concept_Name XK469
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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