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Version: 17.06d (Release date: 2017-06-26)
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Ertumaxomab (Code C2658)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ertumaxomab

Definition: A murine monoclonal antibody with two antigen-recognition sites: one for CD3, an antigen expressed on mature T cells, and one for HER-2-neu, a tumor-associated antigen that promotes tumor growth. Ertumaxomab attaches to CD3-expressing T cells and HER-2-neu-expressing tumor cells, selectively cross-linking tumor and immunologic cells which results in the recruitment of cytotoxic T cells to the T cell/tumor cell aggregate.

Display Name: Ertumaxomab

Label: Ertumaxomab

NCI Thesaurus Code: C2658 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1723386  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-CD3 x anti-HER-2-neu Bispecific Monoclonal Antibody
Ertumaxomab

External Source Codes: 
PDQ Closed Trial Search ID 38498
PDQ Open Trial Search ID 38498 (check for NCI PDQ open clinical trial info)
UMLS CUI C1723386

Other Properties:
     Name Value (qualifiers indented underneath)
code C2658
Contributing_Source CTRP
Legacy_Concept_Name Anti-CD3_x_anti-HER-2-neu_Bispecific_Monoclonal_Antibody
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2658

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