skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Halofuginone Hydrobromide (Code C2656)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Halofuginone Hydrobromide

Definition: The hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.

NCI-GLOSS Definition: A substance that is being studied for its ability to slow the growth of connective tissue and to prevent the growth of new blood vessels that tumors need to grow. It is a type of quinazolinone alkaloid and a type of antiangiogenesis agent.

Display Name: Halofuginone Hydrobromide

Label: Halofuginone Hydrobromide

NCI Thesaurus Code: C2656 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0521922  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Halofuginone Hydrobromide
halofuginone hydrobromide
Halofuginone hydrobromide
Halofuginone IV (intravenous)
RU 19110

External Source Codes: 
CAS Registry Number 64924-67-0 (see NLM ChemIDplus info)
CAS Registry Number 17395-31-2 (see NLM ChemIDplus info)
NSC Code 713205 (see NCI DTP info)
PDQ Closed Trial Search ID 38485
PDQ Open Trial Search ID 38485 (check for NCI PDQ open clinical trial info)
UMLS CUI C0521922

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Scleroderma and Antiprotozoal; Coccidiosis (Vet).
Chemical_Formula C16H17BrClN3O3.BrH
code C2656
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Halofuginone_Hydrobromide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


Mainbox Bottom