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Version: 17.06d (Release date: 2017-06-26)
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Ipilimumab (Code C2654)

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Terms & Properties

Preferred Name: Ipilimumab

Definition: A recombinant human immunoglobulin (Ig) G1 monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), with immune checkpoint inhibitory and antineoplastic activities. Ipilimumab binds to CTLA4 expressed on T-cells and inhibits the CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system.

NCI-GLOSS Definition: A monoclonal antibody being studied in the treatment of certain types of cancer. Ipilimumab is made in the laboratory and binds to the molecule CTLA-4 on T cells (a type of white blood cell). Ipilimumab may block CTLA-4 and help the immune system kill cancer cells.

Display Name: Ipilimumab

Label: Ipilimumab

NCI Thesaurus Code: C2654 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1367202  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody

External Source Codes: 
CAS Registry Number 477202-00-9 (see NLM ChemIDplus info)
FDA UNII Code 6T8C155666
NSC Code 732442 (see NCI DTP info)
NSC Code 720801 (see NCI DTP info)
PDQ Closed Trial Search ID 38447
PDQ Open Trial Search ID 38447 (check for NCI PDQ open clinical trial info)
UMLS CUI C1367202

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Unresectable or Metastatic Melanoma
code C2654
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-Cytotoxic_T-Lymphocyte-Associated_Antigen-4_Monoclonal_Antibody
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


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