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Version: 16.11d (Release date: 2016-11-28)
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Laromustine (Code C2653)

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Terms & Properties

Preferred Name: Laromustine

Definition: A sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream; 90CE chloroethylates alkylates the O6 position of guanine, resulting in DNA crosslinking, strand breaks, chromosomal aberrations, and disruption of DNA synthesis. Intracellular metabolism of this agent also releases methyl isocyanate which inhibits O6-alkyl-guanine transferase, an enzyme involved with DNA repair.

NCI-GLOSS Definition: A drug used to treat acute myelogenous leukemia (AML). It is also being studied in the treatment of several other types of cancer. It blocks cell growth by damaging the cell's DNA and may kill cancer cells. It is a type of alkylating agent.

Display Name: Laromustine

Label: Laromustine

NCI Thesaurus Code: C2653 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2713559  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine
101M
Cloretazine
Laromustine
LAROMUSTINE
laromustine
Onrigin
VNP40101M

External Source Codes: 
CAS Registry Number 173424-77-6 (see NLM ChemIDplus info)
FDA UNII Code 14J2G0U3NQ
NSC Code 734246 (see NCI DTP info)
PDQ Closed Trial Search ID 38440
PDQ Open Trial Search ID 38440 (check for NCI PDQ open clinical trial info)
UMLS CUI C2713559

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C6H14ClN3O5S2
code C2653
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name VNP40101M
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2653

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