skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
DHA-Paclitaxel (Code C2649)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: DHA-Paclitaxel

Definition: A prodrug comprised of the naturally occurring omega-3 fatty acid docosahexaenoic acid (DHA) covalently conjugated to the anti-microtubule agent paclitaxel. Because tumor cells take up DHA, DHA-paclitaxel is delivered directly to tumor tissue, where the paclitaxel moiety binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. Paclitaxel also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). DHA-paclitaxel exhibits improved pharmacokinetic and toxicity profiles when compared to conventional paclitaxel and has demonstrated antineoplastic activity in animal models of cancer. (NCI04)

NCI-GLOSS Definition: A combination of DHA (a natural fatty acid) and paclitaxel (an anticancer drug) being studied in the treatment of cancer. It is a type of mitotic inhibitor.

Display Name: DHA-Paclitaxel

Label: DHA-Paclitaxel

NCI Thesaurus Code: C2649 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1134470  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DHA-Paclitaxel
DHA-paclitaxel
Docosahexaenoic Acid-Paclitaxel conjugate
Taxoprexin
TXP

External Source Codes: 
CAS Registry Number 73-67-6 (see NLM ChemIDplus info)
NSC Code 28247 (see NCI DTP info)
PDQ Closed Trial Search ID 38414
PDQ Open Trial Search ID 38414 (check for NCI PDQ open clinical trial info)
UMLS CUI C1134470

Other Properties:
     Name Value (qualifiers indented underneath)
code C2649
Contributing_Source CTRP
Legacy_Concept_Name DHA-Paclitaxel
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2649

Mainbox Bottom