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Version: 17.06d (Release date: 2017-06-26)
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Methyl-5-Aminolevulinate Hydrochloride Cream (Code C2647)

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Terms & Properties

Preferred Name: Methyl-5-Aminolevulinate Hydrochloride Cream

Definition: A topical cream formulation containing the hydrochloride salt of methyl-5-aminolevulinate, a lipophilic methyl ester of 5-aminolevulinic acid, with photosensitizer prodrug activity. Upon topical administration, methyl-5-aminolevulinate in the cream is selectively absorbed by tumor cells where it is converted to the photosensitizer protoporphyrin IX (PpIX). Upon photoirradiation, PpIX is activated and transfers energy to oxygen, generating singlet oxygen and superoxide and hydroxyl radicals, which may result in free-radical-mediated DNA damage and cell death.

NCI-GLOSS Definition: A drug used in photodynamic therapy; it is absorbed by tumor cells and, when exposed to light, becomes active and kills the cancer cells.

Display Name: Methyl-5-Aminolevulinate Hydrochloride Cream

Label: Methyl-5-Aminolevulinate Hydrochloride Cream

NCI Thesaurus Code: C2647 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2713112  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
methyl-5-aminolevulinate
Methyl-5-Aminolevulinate Hydrochloride Cream
Methyl Aminolevulinate Hydrochloride Cream
Metvix
Metvixia

External Source Codes: 
PDQ Closed Trial Search ID 38410
PDQ Open Trial Search ID 38410 (check for NCI PDQ open clinical trial info)
UMLS CUI C2713112

Other Properties:
     Name Value (qualifiers indented underneath)
code C2647
Contributing_Source CTRP
Legacy_Concept_Name Methyl-5-Aminolevulinate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2647

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