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Version: 17.06d (Release date: 2017-06-26)
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Doxercalciferol (Code C2645)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Doxercalciferol

Definition: A synthetic analog of vitamin D with potential antineoplastic activity. In the liver, doxercalciferol is converted to its biologically active vitamin D metabolites, which control the intestinal absorption of dietary calcium, the tubular reabsorption of calcium by the kidney and, in conjunction with parathyroid hormone (PTH), the mobilization of calcium from the skeleton. Through interaction with specific receptor proteins in target tissues, these vitamin D metabolites act directly on osteoblasts to stimulate skeletal growth, and on the parathyroid glands to suppress PTH synthesis and secretion. This agent has also been shown to inhibit the growth of retinoblastomas, and may exhibit some antiproliferative activity against prostate cancer cells.

NCI-GLOSS Definition: A substance being studied in the prevention of recurrent prostate cancer. It is a type of vitamin D analog.

Display Name: Doxercalciferol

Label: Doxercalciferol

NCI Thesaurus Code: C2645 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0043668  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(1alpha,3beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol
1-Alpha-Hydroxyvitamin D2
Doxercalciferol
DOXERCALCIFEROL
doxercalciferol
Hectorol

External Source Codes: 
CAS Registry Number 54573-75-0 (see NLM ChemIDplus info)
FDA UNII Code 3DIZ9LF5Y9
PDQ Closed Trial Search ID 38406
PDQ Open Trial Search ID 38406 (check for NCI PDQ open clinical trial info)
UMLS CUI C0043668

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Secondary hyperparathyroidism in end stage renal disease in patients on hemodialysis.
Chemical_Formula C28H44O2
code C2645
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Doxercalciferol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2645

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