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Version: 16.11d (Release date: 2016-11-28)
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Abagovomab (Code C26449)

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Terms & Properties

Preferred Name: Abagovomab

Definition: A murine IgG1 monoclonal anti-idiotype antibody, containing a variable antigen-binding region that functionally mimics the three-dimensional structure of a specific epitope on the ovarian cancer tumor-associated antigen CA-125, with potential antineoplastic activity. With a variable antigen-binding region that acts as a surrogate antigen for CA-125, abagovomab may stimulate the host immune system to elicit humoral and cellular immune responses against CA-125-positive tumor cells, resulting in inhibition of tumor cell proliferation.

Display Name: Abagovomab

Label: Abagovomab

NCI Thesaurus Code: C26449 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1832044  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Abagovomab
ABAGOVOMAB
Monoclonal Antibody ACA125 Anti-Idiotype Vaccine
VaccinOvar

External Source Codes: 
CAS Registry Number 792921-10-9 (see NLM ChemIDplus info)
FDA UNII Code 3YK0326U7X
PDQ Closed Trial Search ID 299488
PDQ Open Trial Search ID 299488 (check for NCI PDQ open clinical trial info)
UMLS CUI C1832044

Other Properties:
Name Value (qualifiers indented underneath)
code C26449
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Monoclonal_Antibody_ACA125_Anti-Idiotype_Vaccine
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26449

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