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Version: 16.11d (Release date: 2016-11-28)
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Galiximab (Code C26447)

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Terms & Properties

Preferred Name: Galiximab

Definition: A chimeric IgG1 monoclonal antibody directed against CD80, the natural ligand for the T-cell antigen CD28 which mediates T-cell and B-cell adhesion. Galiximab binds to CD80 expressed on the cell surfaces of follicular lymphomas, resulting in antibody-dependent cell-mediated cytotoxicity (ADCC). CD80 is expressed on activated B-cells and gamma-interferon-stimulated monocytes and is often expressed at low levels on the surfaces of follicular lymphoma cells and other lymphoid malignancies.

NCI-GLOSS Definition: A substance being studied in the treatment of follicular non-Hodgkin lymphoma. It binds to the protein CD80, which is found on certain normal white blood cells and on white blood cells that are cancer. It is a type of monoclonal antibody.

Display Name: Galiximab

Label: Galiximab

NCI Thesaurus Code: C26447 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1098262  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
anti-B7-1
anti-CD80 Antibody
Galiximab
GALIXIMAB
galiximab
IDEC-114

External Source Codes: 
CAS Registry Number 357613-77-5 (see NLM ChemIDplus info)
FDA UNII Code S9OX9692ZB
NSC Code 734532 (see NCI DTP info)
PDQ Closed Trial Search ID 285686
PDQ Open Trial Search ID 285686 (check for NCI PDQ open clinical trial info)
UMLS CUI C1098262

Other Properties:
Name Value (qualifiers indented underneath)
code C26447
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name IDEC-114_Monoclonal_Antibody
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26447

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