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Version: 17.06d (Release date: 2017-06-26)
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Golnerminogene Pradenovec (Code C26444)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Golnerminogene Pradenovec

Definition: A recombinant agent consisting of a genetically-modified adenovirus 5 vector encoding the protein cytokine tumor necrosis factor (TNF) alpha. TNF exhibits potent anti-tumor cytolytic properties; the adenovirus 5 vector efficiently infects tumor cells, delivering tumor-specific TNF.

NCI-GLOSS Definition: A gene therapy product that is being studied in combination with radiation therapy in the treatment of cancer.

Display Name: Golnerminogene Pradenovec

Label: Golnerminogene Pradenovec

NCI Thesaurus Code: C26444 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1327819  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Adenovirus 5-Tumor Necrosis Factor Alpha
ADgv EGR.TNF.11D
Ad 5-TNF Alpha
Golnerminogene Pradenovec
TNFerade

External Source Codes: 
CAS Registry Number 957472-14-9 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 258431
PDQ Open Trial Search ID 258431 (check for NCI PDQ open clinical trial info)
UMLS CUI C1327819

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Treatment of solid tumors including pancreatic cancer
code C26444
Contributing_Source CTRP
Legacy_Concept_Name Adenovirus_5-Tumor_Necrosis_Factor_Alpha
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26444

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