|Idronoxil (Code C2642)|
|Terms & Properties|
Preferred Name: Idronoxil
Definition: A synthetic flavonoid derivative. Idronoxil activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis (XIAP), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex, thereby preventing DNA replication and resulting in tumor cell death.
NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called signal transduction inhibitors.
Display Name: Idronoxil
NCI Metathesaurus Link: C1134444 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|CAS Registry Number||81267-65-4 (see NLM ChemIDplus info)|
|FDA UNII Code||995FT1W541|
|PDQ Closed Trial Search ID||38371|
|PDQ Open Trial Search ID||38371 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|