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Version: 17.06d (Release date: 2017-06-26)
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Idronoxil (Code C2642)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Idronoxil

Definition: A synthetic flavonoid derivative. Idronoxil activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis (XIAP), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex, thereby preventing DNA replication and resulting in tumor cell death.

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called signal transduction inhibitors.

Display Name: Idronoxil

Label: Idronoxil

NCI Thesaurus Code: C2642 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1134444  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol
Idronoxil
IDRONOXIL
NOX66
NV-06
phenoxodiol
Phenoxodiol

External Source Codes: 
CAS Registry Number 81267-65-4 (see NLM ChemIDplus info)
FDA UNII Code 995FT1W541
PDQ Closed Trial Search ID 38371
PDQ Open Trial Search ID 38371 (check for NCI PDQ open clinical trial info)
UMLS CUI C1134444

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H12O3
code C2642
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Phenoxodiol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2642

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