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Version: 17.06d (Release date: 2017-06-26)
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Canfosfamide Hydrochloride (Code C2641)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Canfosfamide Hydrochloride

Definition: The hydrochloride salt of a modified glutathione analogue with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies.

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called glutathione analogs.

Display Name: Canfosfamide Hydrochloride

Label: Canfosfamide Hydrochloride

NCI Thesaurus Code: C2641 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1258106  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Canfosfamide Hydrochloride
CANFOSFAMIDE HYDROCHLORIDE
canfosfamide hydrochloride
Telcyta
TLK286

External Source Codes: 
CAS Registry Number 439943-59-6 (see NLM ChemIDplus info)
FDA UNII Code 1LI341K7NQ
PDQ Closed Trial Search ID 38367
PDQ Open Trial Search ID 38367 (check for NCI PDQ open clinical trial info)
UMLS CUI C1258106

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C26H40Cl4N5O10PS.HCl
code C2641
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name TLK286
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2641

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