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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Canfosfamide Hydrochloride (Code C2641)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Canfosfamide Hydrochloride

Definition: The hydrochloride salt of a modified glutathione analogue with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies.

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called glutathione analogs.

Display Name: Canfosfamide Hydrochloride

Label: Canfosfamide Hydrochloride

NCI Thesaurus Code: C2641 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1258106  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Canfosfamide Hydrochloride
canfosfamide hydrochloride

External Source Codes: 
CAS Registry Number 439943-59-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 38367
PDQ Open Trial Search ID 38367 (check for NCI PDQ open clinical trial info)
UMLS CUI C1258106

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C26H40Cl4N5O10PS.HCl
code C2641
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name TLK286
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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