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Version: 17.08d (Release date: 2017-08-28)
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Taurolidine (Code C2639)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Taurolidine

Definition: A synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities. Taurolidine, derived from the amino acid taurine, binds to and neutralizes bacterial exotoxins and endotoxins, or lipopolysaccharides (LPS). Taurolidine binding to LPS prevents bacterial adherence to host epithelial cells, thereby prevents bacterial invasion of uninfected host cells. Although the mechanism underlying its antineoplastic activity has not been fully elucidated, it may be related to this agent's anti-adherence property. In addition, taurolidine also promotes apoptosis by inducing various apoptotic factors and suppresses the production of vascular endothelial growth factor (VEGF), a protein that plays an important role in angiogenesis.

NCI-GLOSS Definition: A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called anti-infectives.

Label: Taurolidine

NCI Thesaurus Code: C2639 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0144567  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Bis(1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)-methane
taurolidine
Taurolidine
TAUROLIDINE
Taurolin

External Source Codes: 
CAS Registry Number 19388-87-5 (see NLM ChemIDplus info)
FDA UNII Code 8OBZ1M4V3V
PDQ Closed Trial Search ID 38354
PDQ Open Trial Search ID 38354 (check for NCI PDQ open clinical trial info)
UMLS CUI C0144567

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Bronchiectasis; Catheter-Related Sepsis; Otitis Media; Peritonitis; Thoracic Empyema
Chemical_Formula C7H16N4O4S2
code C2639
Contributing_Source FDA
Legacy_Concept_Name Taurolidine
Semantic_Type Antibiotic

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2639

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