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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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HPPH (Code C2636)

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Terms & Properties

Preferred Name: HPPH

Definition: A lipophilic, second-generation, chlorin-based photosensitizer. Upon intravenous administration, HPPH selectively accumulates in the cytoplasm of cancer or pre-cancerous cells. When laser light is applied, a photodynamic reaction between HPPH and oxygen occurs, resulting in the production of cytotoxic free radicals and singlet oxygen and free radical-mediated cell death. Compared to the first-generation photosensitizer porfimer sodium, HPPH shows improved pharmacokinetic properties and causes only mild skin photosensitivity which declines rapidly within a few days after administration.

NCI-GLOSS Definition: A drug that is used in photodynamic therapy that is absorbed by tumor cells; when exposed to light, it becomes active and kills the cancer cells.

Display Name: HPPH

Label: HPPH

NCI Thesaurus Code: C2636 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0248392  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-(1-Hexyloxyethyl)-2-Devinyl Pyropheophorbide-a

External Source Codes: 
CAS Registry Number 149402-51-7 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 38335
PDQ Open Trial Search ID 38335 (check for NCI PDQ open clinical trial info)
UMLS CUI C0248392

Other Properties:
     Name Value (qualifiers indented underneath)
code C2636
Contributing_Source CTRP
Legacy_Concept_Name HPPH
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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