skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 16.11d (Release date: 2016-11-28)
SearchBox Top
SearchBox Bottom
Pirfenidone (Code C2635)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Pirfenidone

Definition: An orally active synthetic antifibrotic agent structurally similar to pyridine 2,4-dicarboxylate. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tumor cell proliferation. This agent also inhibits DNA synthesis and the production of mRNA for collagen types I and III, resulting in a reduction in radiation-induced fibrosis. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the prevention and treatment of scar tissue caused by radiation therapy. It belongs to the family of drugs called anti-inflammatory agents.

Label: Pirfenidone

NCI Thesaurus Code: C2635 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0298067  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PIRFENIDONE
Pirfenidone
pirfenidone

External Source Codes: 
CAS Registry Number 53179-13-8 (see NLM ChemIDplus info)
FDA UNII Code D7NLD2JX7U
PDQ Closed Trial Search ID 38334
PDQ Open Trial Search ID 38334 (check for NCI PDQ open clinical trial info)
UMLS CUI C0298067

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C12H11NO
code C2635
Contributing_Source FDA
Legacy_Concept_Name Pirfenidone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2635

Mainbox Bottom