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Version: 17.10e (Release date: 2017-10-30)
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Pirfenidone (Code C2635)

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Terms & Properties

Preferred Name: Pirfenidone

Definition: An orally active synthetic antifibrotic agent structurally similar to pyridine 2,4-dicarboxylate. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tumor cell proliferation. This agent also inhibits DNA synthesis and the production of mRNA for collagen types I and III, resulting in a reduction in radiation-induced fibrosis. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the prevention and treatment of scar tissue caused by radiation therapy. It belongs to the family of drugs called anti-inflammatory agents.

Label: Pirfenidone

NCI Thesaurus Code: C2635 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0298067  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 53179-13-8 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 38334
PDQ Open Trial Search ID 38334 (check for NCI PDQ open clinical trial info)
UMLS CUI C0298067

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C12H11NO
code C2635
Contributing_Source FDA
Legacy_Concept_Name Pirfenidone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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