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Version: 17.06d (Release date: 2017-06-26)
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Pelitrexol (Code C2633)

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Terms & Properties

Preferred Name: Pelitrexol

Definition: A water soluble antifolate with anti-proliferative activity. Pelitrexol inhibits activity of glycinamide ribonucleotide formyltransferase (GARFT), the first folate-dependent enzyme of the de novo purine synthesis pathway essential for cell proliferation. Enzyme inhibition reduces the purine nucleotides pool required for DNA replication and RNA transcription. As a result, this agent causes cell cycle arrest in S-phase, and ultimately inhibits tumor cell proliferation

NCI-GLOSS Definition: A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called glycinamide ribonucleotide formyl transferase inhibitors.

Label: Pelitrexol

NCI Thesaurus Code: C2633 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1871457  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2S)-2-(((5-(2-((6S)-2-Amino-4-oxo-1,4,5,6,7,8-hexahydropyrido(2,3-d)pyrimidin-6-yl)ethyl)-4-methylthiophen-2-yl)carbonyl)amino)pentanedioic Acid
(2S)-2-[[[5-[2-[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl]-4-methylthiophen-2-yl]carbonyl]amino]pentanedioic Acid
AG2037
Pelitrexol
PELITREXOL

External Source Codes: 
CAS Registry Number 446022-33-9 (see NLM ChemIDplus info)
FDA UNII Code DHT6E8M4KP
PDQ Closed Trial Search ID 38329
PDQ Open Trial Search ID 38329 (check for NCI PDQ open clinical trial info)
UMLS CUI C1871457

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C20H25N5O6S
code C2633
Contributing_Source FDA
Legacy_Concept_Name AG2037
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2633

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