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Version: 17.06d (Release date: 2017-06-26)
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Pelitrexol (Code C2633)

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Terms & Properties

Preferred Name: Pelitrexol

Definition: A water soluble antifolate with anti-proliferative activity. Pelitrexol inhibits activity of glycinamide ribonucleotide formyltransferase (GARFT), the first folate-dependent enzyme of the de novo purine synthesis pathway essential for cell proliferation. Enzyme inhibition reduces the purine nucleotides pool required for DNA replication and RNA transcription. As a result, this agent causes cell cycle arrest in S-phase, and ultimately inhibits tumor cell proliferation

NCI-GLOSS Definition: A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called glycinamide ribonucleotide formyl transferase inhibitors.

Label: Pelitrexol

NCI Thesaurus Code: C2633 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1871457  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2S)-2-(((5-(2-((6S)-2-Amino-4-oxo-1,4,5,6,7,8-hexahydropyrido(2,3-d)pyrimidin-6-yl)ethyl)-4-methylthiophen-2-yl)carbonyl)amino)pentanedioic Acid
(2S)-2-[[[5-[2-[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl]-4-methylthiophen-2-yl]carbonyl]amino]pentanedioic Acid

External Source Codes: 
CAS Registry Number 446022-33-9 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 38329
PDQ Open Trial Search ID 38329 (check for NCI PDQ open clinical trial info)
UMLS CUI C1871457

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C20H25N5O6S
code C2633
Contributing_Source FDA
Legacy_Concept_Name AG2037
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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