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Version: 17.06d (Release date: 2017-06-26)
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Paclitaxel Liposome (Code C2631)

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Terms & Properties

Preferred Name: Paclitaxel Liposome

Definition: A liposome-encapsulated formulation of paclitaxel, a taxoid compound extracted from the Pacific yew tree Taxus brevifolia, with antineoplastic property. Paclitaxel binds to tubulin and interferes with the assembly/disassembly dynamics of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis via inactivation of the apoptosis inhibitor, B-cell Leukemia 2 (Bcl-2) protein. Paclitaxel liposome formulation potentially enhances delivery of higher doses of paclitaxel to the target tissues and exhibits lower systemic toxicity.

NCI-GLOSS Definition: A form of the anticancer drug paclitaxel that is contained in very tiny, fat-like particles. It may have fewer side effects and work better than paclitaxel. It is being studied in the treatment of several types of cancer. Paclitaxel liposome blocks the ability of cells to divide and may kill cancer cells. It is a type of mitotic inhibitor and a type of antimicrotubule agent.

Label: Paclitaxel Liposome

NCI Thesaurus Code: C2631 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0935868  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
LEP-ETU
liposomal paclitaxel
Liposome-Encapsulated Paclitaxel
LipoTaxen
Paclitaxel Liposome
paclitaxel liposome
PNU-93914

External Source Codes: 
PDQ Closed Trial Search ID 38323
PDQ Open Trial Search ID 38323 (check for NCI PDQ open clinical trial info)
UMLS CUI C0935868

Other Properties:
     Name Value (qualifiers indented underneath)
code C2631
Legacy_Concept_Name Paclitaxel_Liposome
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2631

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