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Version: 17.12d (Release date: 2017-12-26)
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Valganciclovir (Code C2629)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Valganciclovir

Definition: A synthetic prodrug of ganciclovir, a nucleoside analogue of 2'-deoxyguanosine, with antiviral activity. After phosphorylation, valganciclovir is incorporated into DNA, resulting in inhibition of viral DNA polymerase, viral DNA synthesis, and viral replication. (NCI04)

NCI-GLOSS Definition: An antiviral agent that is being studied as a treatment for AIDS-related cytomegalovirus. It is changed in the body to ganciclovir.

Display Name: Valganciclovir

Label: Valganciclovir

NCI Thesaurus Code: C2629 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0909381  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-3-hydroxypropyl Ester

External Source Codes: 
CAS Registry Number 175865-60-8 (see NLM ChemIDplus info)
ChEBI ID CHEBI:63635 (see ChEBI info)
PDQ Closed Trial Search ID 38289
PDQ Open Trial Search ID 38289 (check for NCI PDQ open clinical trial info)
UMLS CUI C0909381

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Cytomegalovirus retinitis
code C2629
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Valganciclovir
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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