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National Cancer Institute
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Version: 17.08d (Release date: 2017-08-28)
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Benzoylphenylurea (Code C2618)

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Terms & Properties

Preferred Name: Benzoylphenylurea

Definition: A low molecular weight agent with antineoplastic activity. Benzoylphenylurea binds to the colchicine binding site on tubulin, thereby blocking tubulin polymerization and disrupting mitotic function. This agent also inhibits DNA polymerase, and has been shown to arrest leukemia cells in the G1-S transition phase of the cell cycle. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It is a type of antitubulin agent.

Display Name: Benzoylphenylurea

Label: Benzoylphenylurea

NCI Thesaurus Code: C2618 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0935907  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
NSC Code 639829 (see NCI DTP info)
PDQ Closed Trial Search ID 38213
PDQ Open Trial Search ID 38213 (check for NCI PDQ open clinical trial info)
UMLS CUI C0935907

Other Properties:
     Name Value (qualifiers indented underneath)
code C2618
Contributing_Source CTRP
Legacy_Concept_Name Benzoylphenylurea
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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