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National Cancer Institute
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Version: 17.08d (Release date: 2017-08-28)
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EGFR Antisense DNA (Code C2617)

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Terms & Properties

Preferred Name: EGFR Antisense DNA

Definition: A synthetic sequence of DNA constructed in the antisense orientation to a sequence of DNA in epidermal growth factor receptor (EGFR), a member of the erbB gene family. EGFR antisense DNA suppresses the expression of EGFR by tumor cells, thereby inhibiting tumor cell proliferation and decreasing tumor growth. This agent also appears to reduce the invasiveness of certain breast cancer cells. Members of the erbB gene family are overexpressed in many cancers and play roles in carcinogenesis and the regulation of cell proliferation. (NCI04)

Display Name: EGFR Antisense DNA

Label: EGFR Antisense DNA

NCI Thesaurus Code: C2617 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0935778  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EGFR Antisense DNA

External Source Codes: 
PDQ Closed Trial Search ID 38201
PDQ Open Trial Search ID 38201 (check for NCI PDQ open clinical trial info)
UMLS CUI C0935778

Other Properties:
     Name Value (qualifiers indented underneath)
code C2617
Contributing_Source CTRP
Legacy_Concept_Name EGFR_Antisense_DNA
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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