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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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SS1(dsFv)-PE38 Immunotoxin (Code C2609)

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Terms & Properties

Preferred Name: SS1(dsFv)-PE38 Immunotoxin

Definition: A recombinant immunotoxin consisting of the single chain anti-mesothelin monoclonal antibody SS1(dsFv) linked to Pseudomonas exotoxin PE-38. The monoclonal antibody moiety of the agent binds to cells that express mesothelin, a cell surface glycoprotein which may be overexpressed in ovarian cancer, mesotheliomas, and some squamous cell carcinomas; after internalization, the exotoxin moiety inactivates eukaryotic translation elongation factor 2, thereby disrupting tumor cell protein synthesis. (NCI04)

Display Name: SS1(dsFv)-PE38 Immunotoxin

Label: SS1(dsFv)-PE38 Immunotoxin

NCI Thesaurus Code: C2609 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1258770  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Immunotoxin, SS1(dsFv)-PE38
SS1(dsFv) PE38
SS1(dsFv)-PE38 Immunotoxin

External Source Codes: 
NSC Code 726388 (see NCI DTP info)
PDQ Closed Trial Search ID 38156
PDQ Open Trial Search ID 38156 (check for NCI PDQ open clinical trial info)
UMLS CUI C1258770

Other Properties:
     Name Value (qualifiers indented underneath)
code C2609
Contributing_Source CTRP
Legacy_Concept_Name SS1_dsFv-PE38_Immunotoxin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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