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Version: 17.12d (Release date: 2017-12-26)
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Donepezil Hydrochloride (Code C2603)

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Terms & Properties

Preferred Name: Donepezil Hydrochloride

Definition: The hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby blocking the hydrolysis of the neurotransmitter acetylcholine and, consequently, increasing its activity. This agent may improve neurocognitive function in Alzheimer's disease, reduce sedation associated with opioid treatment of cancer pain, and improve neurocognitive function in patients who have received radiation therapy for primary brain tumors or brain metastases.

Display Name: Donepezil Hydrochloride

Label: Donepezil Hydrochloride

NCI Thesaurus Code: C2603 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0771848  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine Hydrochloride
Donepezil Hydrochloride

External Source Codes: 
CAS Registry Number 142057-77-0 (see NLM ChemIDplus info)
CAS Registry Number 120011-70-3 (see NLM ChemIDplus info)
ChEBI ID CHEBI:4696 (see ChEBI info)
PDQ Closed Trial Search ID 38109
PDQ Open Trial Search ID 38109 (check for NCI PDQ open clinical trial info)
UMLS CUI C0771848

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Alzheimers disease and opioid-induced sedation.
Chemical_Formula C24H29NO3.HCl
code C2603
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Donepezil
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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