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Version: 17.04d (Release date: 2017-04-24)
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Yttrium Y 90-Edotreotide (Code C2601)

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Terms & Properties

Preferred Name: Yttrium Y 90-Edotreotide

Definition: A radioconjugate consisting of the octreotide derivative edotreotide labeled with yttrium 90 (Y-90) with potential radiotherapeutic uses. Similar to octreotide, yttrium Y 90-edotreotide binds to somatostatin receptors (SSTRs), especially type 2 receptors, present on the cell membranes of many types of neuroendocrine tumor cells, delivering tissue-specific, beta-emitting nuclide Y-90-mediated cytotoxicity to SSTR-positive cells. Yttrium Y 90-edotreotide is produced by substituting tyrosine for phenylalanine at the 3 position of the somatostatin analogue octreotide and chelating the substituted octreotide to Y-90 via dodecanetetraacetic acid (DOTA).

NCI-GLOSS Definition: A substance being studied in the treatment of some types of cancer. Yttrium Y 90 edotreotide contains yttrium Y 90 (a radioactive form of the metal yttrium) attached to a molecule that binds to certain types of neuroendocrine tumors (tumors that come from cells that release hormones). The radioactivity from yttrium Y 90 may kill the cancer cells.

Display Name: Yttrium Y 90-Edotreotide

Label: Yttrium Y 90-Edotreotide

NCI Thesaurus Code: C2601 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2003893  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EDOTREOTIDE YTTRIUM Y-90
OctreoTher
Onalta
Yttrium Y 90-DOTA-Tyr3-Octreotide
yttrium Y 90-DOTA-tyr3-octreotide
Yttrium Y 90-Edotreotide
Yttrium Y 90 -DOTATOC
yttrium Y 90 edotreotide
Yttrium Y 90 SMT 487
yttrium Y 90 SMT 487

External Source Codes: 
FDA UNII Code ABF7OG3FA3
PDQ Closed Trial Search ID 38102
PDQ Open Trial Search ID 38102 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 20168290 (see PubMed Primary Reference info)
UMLS CUI C2003893

Other Properties:
     Name Value (qualifiers indented underneath)
code C2601
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Yttrium_Y_90_SMT_487
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2601

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