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Version: 17.06d (Release date: 2017-06-26)
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Cintredekin Besudotox (Code C2599)

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Terms & Properties

Preferred Name: Cintredekin Besudotox

Definition: A recombinant chimeric protein with potent antitumor activity. Cintredekin besudotox is composed of interleukin-13 (IL13), a pleiotropic immunoregulatory cytokine, linked to a mutated form of pseudomonas exotoxin A; this agent targets and kills tumor cells that express the IL13 receptor (IL13R).The IL13 moiety attaches to the IL13R on the tumor cell membrane, facilitating the entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It is made by combining interleukin-13 with a toxin from Pseudomonas bacteria. It is a type of recombinant chimeric protein.

Display Name: Cintredekin Besudotox

Label: Cintredekin Besudotox

NCI Thesaurus Code: C2599 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1434448  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cintredekin Besudotox
CINTREDEKIN BESUDOTOX
IL-13 Toxin
IL 13-PE38QQR
Interleukin-13 PE38QQR Immunotoxin
interleukin-13 PE38QQR immunotoxin

External Source Codes: 
CAS Registry Number 372075-36-0 (see NLM ChemIDplus info)
FDA UNII Code ZL04JX89M7
NSC Code 722759 (see NCI DTP info)
PDQ Closed Trial Search ID 38095
PDQ Open Trial Search ID 38095 (check for NCI PDQ open clinical trial info)
UMLS CUI C1434448

Other Properties:
     Name Value (qualifiers indented underneath)
code C2599
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Interleukin-13_PE38QQR_Immunotoxin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2599

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