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Version: 17.06d (Release date: 2017-06-26)
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Therapeutic Autologous Dendritic Cells (Code C2594)

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Terms & Properties

Preferred Name: Therapeutic Autologous Dendritic Cells

Definition: A population of a type of antigen-presenting cell (APC), the dendritic cell (DC), harvested from a patient and grown in vitro in the presence of tumor-associated antigens (TAAs) derived from the patient's tumor (a technique known as 'pulsing') and then injected back into the patient; autologous DCs so manipulated may stimulate a specific cell-mediated antitumoral cytotoxicity. DCs derived from a patient may also be fused with the patient's tumor cells in vitro to combine sustained tumor antigen expression with the antigen-presenting and immunostimulatory capacities of DCs; when injected back into the patient, these autologous DC-tumor cell hybrids (fusion cells) may stimulate an active antitumoral immune response.

Display Name: Therapeutic Autologous Dendritic Cells

Label: Therapeutic Autologous Dendritic Cells

NCI Thesaurus Code: C2594 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0879593  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Therapeutic Autologous Dendritic Cells

External Source Codes: 
NSC Code 727000 (see NCI DTP info)
PDQ Closed Trial Search ID 38048
PDQ Open Trial Search ID 38048 (check for NCI PDQ open clinical trial info)
UMLS CUI C0879593

Other Properties:
     Name Value (qualifiers indented underneath)
code C2594
Contributing_Source CTRP
Legacy_Concept_Name Autologous_Dendritic_Cells
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2594

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