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Version: 17.06d (Release date: 2017-06-26)
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HER-2/neu Intracellular Domain Protein (Code C2593)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: HER-2/neu Intracellular Domain Protein

Definition: The cytoplasmic domain or intracellular domain (ICD) of the HER2/neu protein that exhibits tyrosine kinase activity. Based on sensitization theory, co-administration of trastuzumab (anti-HER-2/neu monoclonal antibody) and HER-2/neu intracellular domain protein may result in the potentiation of a HER2/neu-specific cytotoxic T lymphocyte (CTL) response against tumor cells overexpressing the HER2/neu protein. HER-2/neu protein, a glycoprotein cell surface receptor that is composed of an extracellular domain (ECD), a transmembrane domain, and an ICD, is overexpressed by many adenocarcinomas including breast adenocarcinoma.

Display Name: HER-2/neu Intracellular Domain Protein

Label: HER-2/neu Intracellular Domain Protein

NCI Thesaurus Code: C2593 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3146228  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HER-2/neu ICD Protein
HER-2/neu Intracellular Domain Protein
HER-2 ICD Peptide
HER2 ICD
HER2 Intracellular Domain

External Source Codes: 
PDQ Closed Trial Search ID 38047
PDQ Open Trial Search ID 38047 (check for NCI PDQ open clinical trial info)
UMLS CUI C3146228

Other Properties:
     Name Value (qualifiers indented underneath)
code C2593
Contributing_Source CTRP
Legacy_Concept_Name HER-2_neu_Intracellular_Domain_Protein
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2593

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