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Version: 17.08d (Release date: 2017-08-28)
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St. John's Wort (Code C2589)

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Terms & Properties

Preferred Name: St. John's Wort

Definition: An herbal extract prepared from the plant Hypericum perforatum (St. John's wort) with photodynamic, antineoplastic, and antidepressant activities. Hypericin, one of the active compounds found in Hypericum perforatum, is a photosensitizer that, when exposed to a particular wavelength and intensity of light, may induce tumor cell apoptosis. Another compound, hyperforin, induces caspase-dependent apoptosis in certain tumor cell lines. Hypericum perforatum preparations may also stimulate the activity of cytochrome P450 enzymes and P-glycoprotein drug transporters, resulting in increased metabolism and decreased efficacy of various chemotherapeutic agents and other drugs.

NCI-GLOSS Definition: An herbal product sold as an over-the-counter treatment for depression. It is being studied for its ability to lessen certain side effects of cancer treatment.

Label: St. John's Wort

NCI Thesaurus Code: C2589 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0813171  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
hypericum perforatum
Hypericum Perforatum Extract
St. John's Wort
St. John's wort
St John's Wort

External Source Codes: 
CAS Registry Number 84082-80-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 37989
PDQ Open Trial Search ID 37989 (check for NCI PDQ open clinical trial info)
UMLS CUI C0813171

Other Properties:
     Name Value (qualifiers indented underneath)
code C2589
Contributing_Source FDA
Legacy_Concept_Name Hypericum_Perforatum
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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