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Version: 16.11d (Release date: 2016-11-28)
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St. John's Wort (Code C2589)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: St. John's Wort

Definition: An herbal extract prepared from the plant Hypericum perforatum (St. John's wort) with photodynamic, antineoplastic, and antidepressant activities. Hypericin, one of the active compounds found in Hypericum perforatum, is a photosensitizer that, when exposed to a particular wavelength and intensity of light, may induce tumor cell apoptosis. Another compound, hyperforin, induces caspase-dependent apoptosis in certain tumor cell lines. Hypericum perforatum preparations may also stimulate the activity of cytochrome P450 enzymes and P-glycoprotein drug transporters, resulting in increased metabolism and decreased efficacy of various chemotherapeutic agents and other drugs.

NCI-GLOSS Definition: An herbal product sold as an over-the-counter treatment for depression. It is being studied for its ability to lessen certain side effects of cancer treatment.

Label: St. John's Wort

NCI Thesaurus Code: C2589 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0813171  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
hypericum perforatum
Hypericum Perforatum Extract
ST. JOHN'S WORT
St. John's Wort
St. John's wort
St John's Wort

External Source Codes: 
CAS Registry Number 84082-80-4 (see NLM ChemIDplus info)
FDA UNII Code UFH8805FKA
PDQ Closed Trial Search ID 37989
PDQ Open Trial Search ID 37989 (check for NCI PDQ open clinical trial info)
UMLS CUI C0813171

Other Properties:
Name Value (qualifiers indented underneath)
code C2589
Contributing_Source FDA
Legacy_Concept_Name Hypericum_Perforatum
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2589

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