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Version: 17.06d (Release date: 2017-06-26)
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Annamycin Liposomal (Code C25838)

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Terms & Properties

Preferred Name: Annamycin Liposomal

Definition: A liposome-encapsulated form of the semi-synthetic doxorubicin analogue annamycin with antineoplastic activity. Annamycin intercalates into DNA and inhibits topoisomerase II, resulting in the inhibition of DNA replication and repair and RNA and protein synthesis. This agent circumvents multidrug-resistance (MDR) transporters, including P-glycoprotein (P-gp). Liposomal annamycin is less toxic and shows improved antitumor activity compared to annamycin.

Display Name: Annamycin Liposomal

Label: Annamycin Liposomal

NCI Thesaurus Code: C25838 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0935796  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Annamycin Liposomal

External Source Codes: 
NSC Code 700363 (see NCI DTP info)
PDQ Closed Trial Search ID 38230
PDQ Open Trial Search ID 38230 (check for NCI PDQ open clinical trial info)
UMLS CUI C0935796

Other Properties:
     Name Value (qualifiers indented underneath)
code C25838
Contributing_Source CTRP
Legacy_Concept_Name Annamycin_Liposomal
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  


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