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Version: 17.06d (Release date: 2017-06-26)
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Indium In-111 Ibritumomab Tiuxetan (Code C2579)

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Terms & Properties

Preferred Name: Indium In-111 Ibritumomab Tiuxetan

Definition: A targeted radioimmunoconjugate composed of a murine monoclonal anti-CD20 antibody (ibritumomab) linked by a chelator (tiuxetan) to the imaging radioisotope indium-111. This radioimmunoconjugate binds to CD20-positive cells, permitting radioimmuno-localization of CD20-positive cell biodistribution.

NCI-GLOSS Definition: A radiolabeled monoclonal antibody that is used to detect certain types of B-cell non-Hodgkin lymphoma and is being studied in the detection of other types of B-cell tumors. It is made up of the monoclonal antibody ibritumomab plus the radioisotope indium 111. It binds to the protein called CD20, which is found on B cells. A machine is used to detect which cells in the body have bound the antibody. In 111 ibritumomab tiuxetan is a type of radiopharmaceutical.

Display Name: Indium In-111 Ibritumomab Tiuxetan

Label: Indium In-111 Ibritumomab Tiuxetan

NCI Thesaurus Code: C2579 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0796508  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
IDEC-In2B8
IDEC In2B8
Indium In-111 Ibritumomab Tiuxetan
INDIUM IN-111 IBRITUMOMAB TIUXETAN
indium In 111 ibritumomab tiuxetan
In 111 ibritumomab tiuxetan
In 111 Ibritumomab Tiuxetan
In 111 Zevalin

External Source Codes: 
FDA UNII Code S9U4ZR2W8V
NSC Code 950023 (see NCI DTP info)
PDQ Closed Trial Search ID 43364
PDQ Open Trial Search ID 43364 (check for NCI PDQ open clinical trial info)
UMLS CUI C0796508

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Non-Hodgkins lymphoma
Chemical_Formula C23H27N5O10S.2"H".In
code C2579
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name In_111_Ibritumomab_Tiuxetan
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2579

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