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Version: 17.06d (Release date: 2017-06-26)
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Oglufanide Disodium (Code C2558)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Oglufanide Disodium

Definition: The disodium salt of a synthetic form of a naturally-occurring dipeptide consisting of L-glutamic acid and L-tryptophan with potential antiangiogenic and potential immunomodulating activities. Oglufanide inhibits vascular endothelial growth factor (VEGF), which may inhibit angiogenesis. This agent has also been reported to stimulate the immune response to hepatitic C virus and intracellular bacterial infections.

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors.

Label: Oglufanide Disodium

NCI Thesaurus Code: C2558 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL032903  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Glufanide Disodium
IM-862
IM862
IM 862
L-Tryptophan, L-alpha-glutamyl-, disodium salt
OGLUFANIDE DISODIUM
Oglufanide Disodium
Thymogen

External Source Codes: 
CAS Registry Number 237068-57-4 (see NLM ChemIDplus info)
FDA UNII Code Q60AU1LLNU
PDQ Closed Trial Search ID 43387
PDQ Open Trial Search ID 43387 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 12180893 (see PubMed Primary Reference info)
NCI META CUI CL032903

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C16H17N3O5.2Na
code C2558
Contributing_Source FDA
Legacy_Concept_Name Glufanide_Disodium
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2558

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