|Salmonella VNP20009 (Code C2556)|
|Terms & Properties|
Preferred Name: Salmonella VNP20009
Definition: A genetically stable Salmonella typhimurium strain, attenuated by chromosomal deletion of the purI and msbB genes, with tumor-targeting activity. In rodent models, salmonella VNP20009 has been shown to selectively accumulate and grow in a variety of tumor types, inhibiting the growth of primary and metastatic tumors. This agent may be genetically engineered to contain transgenes that express therapeutic agents or cell surface tumor-associated antigen-specific antibodies, such as CEA-specific antibodies, which may improve its tumor targeting and therapeutic potential.
NCI-GLOSS Definition: A genetically modified Salmonella bacterium that is injected into the tumor. It is being studied for its ability to shrink solid tumors.
Label: Salmonella VNP20009
NCI Metathesaurus Link: C0879622 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
|Auxotrophic Lipid A S. Typhimurium mutant|
|Live, Attenuated Salmonella Typhimurium|
External Source Codes:
|PDQ Closed Trial Search ID||37800|
|PDQ Open Trial Search ID||37800 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|