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Version: 16.11d (Release date: 2016-11-28)
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Salmonella VNP20009 (Code C2556)

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Terms & Properties

Preferred Name: Salmonella VNP20009

Definition: A genetically stable Salmonella typhimurium strain, attenuated by chromosomal deletion of the purI and msbB genes, with tumor-targeting activity. In rodent models, salmonella VNP20009 has been shown to selectively accumulate and grow in a variety of tumor types, inhibiting the growth of primary and metastatic tumors. This agent may be genetically engineered to contain transgenes that express therapeutic agents or cell surface tumor-associated antigen-specific antibodies, such as CEA-specific antibodies, which may improve its tumor targeting and therapeutic potential.

NCI-GLOSS Definition: A genetically modified Salmonella bacterium that is injected into the tumor. It is being studied for its ability to shrink solid tumors.

Label: Salmonella VNP20009

NCI Thesaurus Code: C2556 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0879622  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Auxotrophic Lipid A S. Typhimurium mutant
Live, Attenuated Salmonella Typhimurium
Salmonella VNP20009
VNP20009
VNP 20009

External Source Codes: 
PDQ Closed Trial Search ID 37800
PDQ Open Trial Search ID 37800 (check for NCI PDQ open clinical trial info)
UMLS CUI C0879622

Other Properties:
Name Value (qualifiers indented underneath)
code C2556
Legacy_Concept_Name VNP20009
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2556

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