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Version: 17.08d (Release date: 2017-08-28)
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Vaccine-Sensitized Draining Lymph Node Cells (Code C2542)

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Terms & Properties

Preferred Name: Vaccine-Sensitized Draining Lymph Node Cells

Definition: Cells isolated from lymph nodes from patients, and activated in vitro to generate tumor-specific effector T cells. Lymph nodes in the lymphatics draining tumors often contain T cells that are immunologically sensitized but functionally deficient. Vaccine-sensitized draining lymph node cells are prepared by isolating these lymphocytes in vitro and stimulating them with cytokines to differentiate into mature effector cells. Vaccine-draining lymph node cells may also be produced by pharmacological activation of lymph node-derived lymphocytes with drugs such as ionomycin or with bacterial toxin; these activated lymphocytes may be expanded in culture with cytokines such as interleukin-2 prior to infusion into the patient. (NCI04)

Label: Vaccine-Sensitized Draining Lymph Node Cells

NCI Thesaurus Code: C2542 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0879357  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Vaccine-Sensitized Draining Lymph Node Cells
VDLN Cells

External Source Codes: 
PDQ Closed Trial Search ID 43655
PDQ Open Trial Search ID 43655 (check for NCI PDQ open clinical trial info)
UMLS CUI C0879357

Other Properties:
     Name Value (qualifiers indented underneath)
code C2542
Legacy_Concept_Name Vaccine-Sensitized_Draining_Lymph_Node_Cells
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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