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Version: 17.06d (Release date: 2017-06-26)
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MG 98 (Code C2530)

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Terms & Properties

Preferred Name: MG 98

Definition: A second-generation, mixed-backbone, phosphorothioate antisense oligonucleotide (ODN) with potential antitumor activity. MG 98 is a highly specific inhibitor of translation of the mRNA for human DNA (cytosine-5-)-methyltransferase 1 (DNMT1), hybridizing to the 3' un-translated region of DNMT1 mRNA. The silencing of DNMT1 translation by MG 98 may result in the prevention or reversal of abnormal methylation of tumor suppressor genes and ultimately in tumor growth inhibition or tumor regression.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It blocks the production of a protein called DNA methyltransferase, which helps control gene expression. This may kill cancer cells that need DNA methyltransferase to grow. It is a type of antisense oligonucleotide.

Label: MG 98

NCI Thesaurus Code: C2530 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0796640  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MG-98
MG-98 oligonucleotide
MG98
MG 98

External Source Codes: 
PDQ Closed Trial Search ID 43475
PDQ Open Trial Search ID 43475 (check for NCI PDQ open clinical trial info)
UMLS CUI C0796640

Other Properties:
     Name Value (qualifiers indented underneath)
code C2530
Legacy_Concept_Name MG_98
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2530

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