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Version: 17.06d (Release date: 2017-06-26)
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Iodine I 131 Monoclonal Antibody BC8 (Code C2527)

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Terms & Properties

Preferred Name: Iodine I 131 Monoclonal Antibody BC8

Definition: A radioimmunoconjugate consisting of BC8, a murine IgG1 anti-CD45 monoclonal antibody labeled with iodine 131 (I-131), with radioimmunotherapeutic properties. Using monoclonal antibody BC8 as a carrier for I-131 results in the targeted destruction of cells expressing CD45. CD45 is tyrosine phosphatase expressed on virtually all leukocytes, including myeloid and lymphoid precursors in bone marrow and mature lymphocytes in lymph nodes; it is also expressed on most myeloid and lymphoid leukemic cells, but not on mature erythrocytes or platelets. (NCI04)

NCI-GLOSS Definition: A monoclonal antibody that contains the radioactive substance iodine I131. It is being studied in the treatment of acute myeloid leukemia. Monoclonal antibodies are made in the laboratory and can locate and bind to cancer cells. Iodine I 131 monoclonal antibody BC8 binds to the protein CD45, which is found on most white blood cells and myeloid and lymphoid leukemia cells.

Display Name: Iodine I 131 Monoclonal Antibody BC8

Label: Iodine I 131 Monoclonal Antibody BC8

NCI Thesaurus Code: C2527 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0796627  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
iodine I 131 MOAB BC8
Iodine I 131 Monoclonal Antibody BC8
iodine I 131 monoclonal antibody BC8
I 131 MOAB BC8
I 131 Monoclonal Antibody BC8
MOAB BC8, iodine I 131
monoclonal antibody BC8, iodine I 131

External Source Codes: 
PDQ Closed Trial Search ID 43463
PDQ Open Trial Search ID 43463 (check for NCI PDQ open clinical trial info)
UMLS CUI C0796627

Other Properties:
     Name Value (qualifiers indented underneath)
code C2527
Contributing_Source CTRP
Legacy_Concept_Name I_131_Monoclonal_Antibody_BC8
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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